Researchers


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Name

University of Liverpool

Location

Liverpool, UK

Contact

Prof Jim Gallagher

Website

https://www.liverpool.ac.uk

Description

The University of Liverpool is a public university based in Liverpool, UK and established in 1881. The Department of Musculoskeletal Biology has been conducting research into AKU since 2005.

In DevelopAKUre, the university leads on sample analysis (in particular the histology of cartilage samples), data collection and storage. It also leads on the statistical analysis of results.


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Name

Nordic Bioscience

Location

Herlev, Denmark

Contact

Dr Federica Genovese

Website

http://www.nordicbioscience.com/

Description

Nordic Bioscience is an independent research organisation that specialises in the development of biological markers (biomarkers) for osteoporosis, osteoarthritis, cardiovascular disease, diabetes and other serious illnesses.

In DevelopAKUre, Nordic will lead on the analysis of several biomarkers indicating changes to the progression of AKU disease.


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Name

University of Siena

Location

Siena, Italy

Contact

Prof Annalisa Santucci

Website

http://en.unisi.it

Description

The University of Siena is a public university based in Siena. It was founded in 1240, making it one of the oldest universities in Italy. The Laboratory of Cellular Biochemistry will lead on the university’s contribution to DevelopAKUre.

The university will lead on analysis of biochemical samples, indicating inflammation and oxidative stress in samples taken from AKU patients.




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Name

Biomedical Research Centre

Location

Bratislava, Slovakia

Contact

Dr Andrea Zatkova

Website

http://www.bmc.sav.sk/

Description

The Biomedical Research Centre forms a part of the Slovak Academy of Sciences (BMC SAS). It includes the Institute of Clinical and Translational Research and the Laboratory of Genetics, which has conducted several studies looking at the molecular analysis of Slovak patients affected by AKU. They will apply their expertise to a wider population of patients as a part of DevelopAKUre.

The institute leads on the genetic analysis of patient samples in DevelopAKUre, in order to better understand new mutations that cause AKU.


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Name

The Royal Liverpool Univeristy Hospital

Location

Liverpool, UK

Contact

Prof Laksminarayan Ranganath

Website

http://www.rlbuht.nhs.uk/Pages/RoyalHome.aspx

Description

In addition to its role as a clinical site, the Royal Liverpool University Hospital also provides research support to the DevelopAKUre clinical trials.

The Department of Clinical Biochemistry analyses patient's blood and urine samples to confirm diagnosis of AKU and to monitor tyrosine and metabolites, providing data on the effectiveness and safety of nitisinone.

 

 
 

Welcome To DevelopAKUre


DevelopAKUre is a series of major international clinical trials, run by a consortium of 12 European partners. It aims to study a potential new drug, called nitisinone, and assess its potential effectiveness in treating the rare disease, alkaptonuria (AKU).

DevelopAKUre is co-funded by a grant from the European Commission. This website is run by a UK patient group, the AKU Society. Learn more about AKU on the AKU Society's What is AKU page.

 

DevelopAKUre Blog

SONIA 2 – Controlling Protein to Support Nitisinone Treatment
11-Jul-2017

In today’s blog Chief investigator Prof. Ranganath reinforces the need for SONIA 2 pat.. ...more

Introducing PhD Student Brendan Norman
16-Feb-2017

In this week's blog, we talk to Brendan Norman, a PhD student at the University Of Liverpool, ab.. ...more