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University of Liverpool |
Location |
Liverpool, UK |
Contact |
Prof Jim Gallagher |
Website |
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Description |
The University of Liverpool is a public university based in Liverpool, UK and established in 1881. The Department of Musculoskeletal Biology has been conducting research into AKU since 2005. In DevelopAKUre, the university leads on sample analysis (in particular the histology of cartilage samples), data collection and storage. It also leads on the statistical analysis of results. |
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Name |
Nordic Bioscience |
Location |
Herlev, Denmark |
Contact |
Dr Federica Genovese |
Website |
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Description |
Nordic Bioscience is an independent research organisation that specialises in the development of biological markers (biomarkers) for osteoporosis, osteoarthritis, cardiovascular disease, diabetes and other serious illnesses. In DevelopAKUre, Nordic will lead on the analysis of several biomarkers indicating changes to the progression of AKU disease. |
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Name |
University of Siena |
Location |
Siena, Italy |
Contact |
Prof Annalisa Santucci |
Website |
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Description |
The University of Siena is a public university based in Siena. It was founded in 1240, making it one of the oldest universities in Italy. The Laboratory of Cellular Biochemistry will lead on the university’s contribution to DevelopAKUre. The university will lead on analysis of biochemical samples, indicating inflammation and oxidative stress in samples taken from AKU patients. |
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Name |
Biomedical Research Centre |
Location |
Bratislava, Slovakia |
Contact |
Dr Andrea Zatkova |
Website |
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Description |
The Biomedical Research Centre forms a part of the Slovak Academy of Sciences (BMC SAS). It includes the Institute of Clinical and Translational Research and the Laboratory of Genetics, which has conducted several studies looking at the molecular analysis of Slovak patients affected by AKU. They will apply their expertise to a wider population of patients as a part of DevelopAKUre. The institute leads on the genetic analysis of patient samples in DevelopAKUre, in order to better understand new mutations that cause AKU. |
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Name |
The Royal Liverpool Univeristy Hospital |
Location |
Liverpool, UK |
Contact |
Prof Laksminarayan Ranganath |
Website |
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Description |
In addition to its role as a clinical site, the Royal Liverpool University Hospital also provides research support to the DevelopAKUre clinical trials. The Department of Clinical Biochemistry analyses patient's blood and urine samples to confirm diagnosis of AKU and to monitor tyrosine and metabolites, providing data on the effectiveness and safety of nitisinone. |
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DevelopAKUre is a series of major international clinical trials, run by a consortium of 12 European partners. It aims to study a potential new drug, called nitisinone, and assess its potential effectiveness in treating the rare disease, alkaptonuria (AKU).
DevelopAKUre is co-funded by a grant from the European Commission. This website is run by a UK patient group, the AKU Society. Learn more about AKU on the AKU Society's What is AKU page.
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