Researchers

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Name	University of Liverpool
Location	Liverpool, UK
Contact	Prof Jim Gallagher
Website	https://www.liverpool.ac.uk
Description	The University of Liverpool is a public university based in Liverpool, UK and established in 1881. The Department of Musculoskeletal Biology has been conducting research into AKU since 2005. In DevelopAKUre, the university leads on sample analysis (in particular the histology of cartilage samples), data collection and storage. It also leads on the statistical analysis of results.

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Name	Nordic Bioscience
Location	Herlev, Denmark
Contact	Dr Federica Genovese
Website	http://www.nordicbioscience.com/
Description	Nordic Bioscience is an independent research organisation that specialises in the development of biological markers (biomarkers) for osteoporosis, osteoarthritis, cardiovascular disease, diabetes and other serious illnesses. In DevelopAKUre, Nordic will lead on the analysis of several biomarkers indicating changes to the progression of AKU disease.

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Name	University of Siena
Location	Siena, Italy
Contact	Prof Annalisa Santucci
Website	http://en.unisi.it
Description	The University of Siena is a public university based in Siena. It was founded in 1240, making it one of the oldest universities in Italy. The Laboratory of Cellular Biochemistry will lead on the university’s contribution to DevelopAKUre. The university will lead on analysis of biochemical samples, indicating inflammation and oxidative stress in samples taken from AKU patients.

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Name	Biomedical Research Centre
Location	Bratislava, Slovakia
Contact	Dr Andrea Zatkova
Website	http://www.bmc.sav.sk/
Description	The Biomedical Research Centre forms a part of the Slovak Academy of Sciences (BMC SAS). It includes the Institute of Clinical and Translational Research and the Laboratory of Genetics, which has conducted several studies looking at the molecular analysis of Slovak patients affected by AKU. They will apply their expertise to a wider population of patients as a part of DevelopAKUre. The institute leads on the genetic analysis of patient samples in DevelopAKUre, in order to better understand new mutations that cause AKU.

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Name	The Royal Liverpool Univeristy Hospital
Location	Liverpool, UK
Contact	Prof Laksminarayan Ranganath
Website	http://www.rlbuht.nhs.uk/Pages/RoyalHome.aspx
Description	In addition to its role as a clinical site, the Royal Liverpool University Hospital also provides research support to the DevelopAKUre clinical trials. The Department of Clinical Biochemistry analyses patient's blood and urine samples to confirm diagnosis of AKU and to monitor tyrosine and metabolites, providing data on the effectiveness and safety of nitisinone.